Macrocytosis of the erythrocytes: Post splenectomy and pregnant patients. Suspicion at high level, properly eliciting the history and thorough examination of the patient will lead us in diagnosing macrocytic anemia. Vitamin B12 deficiency may perhaps produce only low grade macrocytic anemia which when persistant for a prolonged duration there is a rapid detoriation, which has been demonstrated in various case studies. Indian J Hematol Blood Transfus.

N Engl J Med. Macrocytic anemia, Non-megaloblastic macrocytic anemia, Bone marrow disorders, Megaloblastic anemia, Myelodysplastic syndrome. A significant proportion of non-vegetarians This demonstrates that megaloblastosis still remains the most significant reason for macrocytic anemia in our population which causes substantial morbidity. Patients above the age of 15 years with macrocytic anemia. A practical approach to the differential diagnosis and evaluation of the adult patient with macrocytic anemia.

Thwsis anemia, Non-megaloblastic macrocytic anemia, Bone marrow disorders, Megaloblastic anemia, Myelodysplastic syndrome. A systematic approach to macrocytosis. Vitamin B12 deficiency may perhaps produce only low grade macrocytic anemia which when persistant for a prolonged duration there is a rapid detoriation, which has been demonstrated in various case studies.

Badhe2 Zachariah Bobby3 and Ashish K.

Macrocytic anema would be wrongly diagnosed as iron deficiency anemia in many of mwcrocytic situations because of similar presentation of variety of anemias. Upper GI endoscopy with deep duodenal biopsy should be done in all patients with megaloblastic anaemia.

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High mean red cell volume: Heterogeneous group of disorders acting via various known and unkwown processes can lead to macrocytic anemia. Received Jun 3; Accepted Sep Result The most common cause of macrocytic anemia was megaloblastic anemia To identify the etiology of macrocytic anemia in patients presenting to tertiary care hospital in South India PSG Hospitals.

thesis on macrocytic anemia

Anemia with a hemoglobin of; a. Low serum B12 vitamin was leading cause of megaloblastic anemia. ABC of clinical hematology: This emphasises the significance of evaluating tropical sprue in a suitable settings to the clinician.

thesis on macrocytic anemia

To evaluate utilization of bone marrow examination and upper GI endoscopy in diagnosis of megaloblastic anemia. Patients with decompensated liver disease, chronic kidney disease, Hemolytic anemia, Hemorrhagic disease.

Patient might present with similar symptoms irrespective of the cause for anemia. Macro-ovalocytes and hyper-segmented neutrophils occurring in peripheral blood smear would significantly favour towards diagnosing megaloblastic anemia.

Patients above the age of 15 years with macrocytic anemia.

Support Center Support Center. Etiology and diagnostic evaluation of macrocytosis. Macrocytosis would be seen even in the absence of anemia.

Etiological Profile of Macrocytic Anemia in Patients Admitted in PSG Hospitals

Disorders that affect the synthesis of DNA in the precursors of erythrocytes leads to megaloblastic anemia and other disorders through various processes causes non-megaloblastic anemia. Tarun Kumar Dutta, Email: A significant proportion of non-vegetarians Considering megaloblastic anaemia as one of the differentials in pancytopenia is important. Sorting out the causes. We observed in our study that being mscrocytic non vegetarian does not protect against Vitamin B12 deficiency.

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The severity of anemia did not have any correlation with the levels of serum B12 or the degree of macrocytosis. Status of laboratory testing in the diagnosis of megaloblastic anemia. Indian J Hematol Blood Transfus. This study was conducted to study the clinical and laboratory parameters in patients with macrocytic anemia and to determine the etiology of macrocytic anemia with special reference to megaloblastic anemia.

Clinico-aetiologic profile of macrocytic anemias with special reference to megaloblastic anemia

National Center for Biotechnology InformationU. When there is no response to iron supplementation after a latent period then only the diagnosis of megaloblastic anemia is offered. To evaluate the causes for megaloblastic anemia. Often we see macrocytosis preceding anemia4,5,6, which is usually not investigated, particularly when anemia is very mild.